The winning play was set up when Mike Hoffman sped down the ice, spun past defenseman Samuel Girard and sent a pass over to Ekblad, whose shot slid through the pads of Semyon Varlamov. The Avalanche fell to 1-12 in OT this season.
Hoffman had a goal midway through the third period to tie the game. Troy Brouwer and Evegenii Dadonov scored 1:09 apart late in the second period to erase a 2-0 deficit. The win moved Luongo past Ed Belfour for third place on the career list.
Brassard nearly had the winner in his Colorado debut on a goal with 12:11 remaining. But his former teammate, Hoffman, stole his thunder by tying it minutes later.
It was a wild day for Brassard, who woke up Monday morning as a member of the Panthers only to be traded to the Avalanche. He was acquired along with a conditional sixth-round draft pick from Florida for a 2020 third-round selection.
Before the game, Brassard said he was going to go out and “have fun. Try to keep it simple.”
The 31-year-old Brassard jumped into the arms of Jost after scoring. He then skated past the Florida bench before bumping fists with his new Colorado teammates.
Trailing 2-0 late in the second period, the Panthers got a goal from Brouwer followed by a power-play score from Dadonov with 24.8 seconds remaining to tie it.
Until then, it was a middle period controlled by the Avalanche. Jost gave them a 1-0 lead early when his wrist shot bounced off Brouwer and past Luongo. Rantanen added another goal on a nifty move when he slammed on the brakes to allow Keith Yandle to slide by and then wired in a shot for his 26th goal.
Varlamov was chosen the NHL’s first star for last week after going 3-0 with a 1.34 goals-against average. He stopped 40 shots in a shutout against Vegas.
NOTES: The Panthers agreed to a three-year extension with forward Frank Vatrano. … Yandle played in his 776th consecutive game, tying him for fifth in NHL history with Craig Ramsay. … Avalanche LW Matt Nieto will be sidelined six to eight weeks with a lower-body injury. “Unfortunate for him. He’s been such a big part of this team and what he brings, his energy,” GM Joe Sakic said. … D Ian Cole (upper body) is skating with the team. Colorado coach Jared Bednar said there’s no timetable for his return.
Panthers: Second game of a back-to-back Tuesday in Arizona.
Avalanche: Conclude a two-game homestand Wednesday against Vancouver.